高血压是动脉粥样硬化的主要危险因素。高血压病经降压药治疗后,脑血管意外、肾功能衰竭、高血压性心肌病等明显减少,但心肌梗塞发病率未见下降,其原因不明。近来发现,多种抗高血压药可使总胆固醇、甘油三酯增加及/或高密度脂蛋白(HDL)减少,以致心血管危险因素增加。因而,选择降压药物时必须注意其不良作用。利尿药噻嗪类氢氯噻嗪、多噻嗪、环戊氯噻嗪、氯帕胺(Clopamide)、苯氟噻嗪和美夫西特(Mefruside)等,可使总胆固醇、甘油三酯、极低密度脂蛋白(VLDL)、低密度脂蛋白 Hypertension is a major risk factor for atherosclerosis. Hypertension after antihypertensive drug treatment, cerebrovascular accident, renal failure, hypertensive cardiomyopathy significantly reduced, but the incidence of myocardial infarction did not decline, the reason is unknown. Recently, it has been found that various antihypertensives can reduce total cholesterol, triglycerides and / or high density lipoprotein (HDL), resulting in increased cardiovascular risk factors. Therefore, the choice of antihypertensive drugs must pay attention to its adverse effects. Diuretics Thiazides hydrochlorothiazide, polythiazide, cyclopentyl thiazide, Clopamide, flubenzene thiazide and mefruside (Mefruside), can make total cholesterol, triglycerides, very low density fat Protein (VLDL), low density lipoprotein