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目的探究缺氧缺血性脑损伤应用纳洛酮联合神经节苷脂的临床疗效。方法 62例缺氧缺血性脑损伤患儿,根据用药不同分为参照组(30例)和研究组(32例)。参照组给予单纯神经节苷脂,研究组给予纳洛酮联合神经节苷脂。比较两组患儿的治疗效果。结果研究组患儿治疗好转率为96.9%(31/32),显著高于参照组的76.7%(23/30)(χ~2=5.63,P<0.05)。第2个疗程末,研究组患儿的新生儿神经行为评价量表(NBNA)评分为(34.42±1.53)分,明显高于参照组的(30.52±1.60)分(t=3.612,P<0.05);第3个疗程末,研究组患儿的NBNA评分为(38.28±1.41)分,显著高于参照组的(33.63±1.59)分(t=4.067,P<0.05)。结论缺氧缺血性脑损伤应用纳洛酮联合神经节苷酯的临床疗效显著,可以有效促进患儿神经功能恢复,临床价值高。
Objective To investigate the clinical efficacy of naloxone in combination with ganglioside in patients with hypoxic-ischemic brain damage. Methods Sixty-two children with hypoxic-ischemic brain damage were divided into the reference group (n = 30) and the study group (n = 32) according to the different drugs. The reference group given simple ganglioside, the study group was given naloxone combined with ganglioside. Compare the treatment effect of two groups of children. Results The rate of improvement in the treatment group was 96.9% (31/32), significantly higher than that in the reference group (76.7%, 23/30) (χ ~ 2 = 5.63, P <0.05). At the end of the second course of treatment, the NBNA score of the study group was (34.42 ± 1.53) points, significantly higher than that of the reference group (30.52 ± 1.60) points (t = 3.612, P <0.05 ). At the end of the third course of treatment, the NBNA score of the study group was (38.28 ± 1.41) points, significantly higher than that of the reference group (33.63 ± 1.59) (t = 4.067, P <0.05). Conclusion The clinical efficacy of naloxone in combination with ganglioside is significant in hypoxic-ischemic brain damage. It can effectively promote the recovery of neurological function in children with high clinical value.