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目的探讨葫芦岛地区育龄期女性甲状腺功能水平与孕前促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPO-Ab)筛查对优生优育的意义。方法选择葫芦岛市1 540例育龄女性,采用罗氏电化学发光E602检测血清TSH、游离甲状腺素(FT4)、游离三碘甲腺原氨酸(FT3)和TPO-Ab。结果 1 540例育龄妇女中,TSH异常135例,总异常率为8.7%,不同年龄组间TSH的异常率差异有统计学意义(χ2=33.56,P<0.05)。TPO-Ab总阳性率为8.2%,TSH正常与异常组间的比较差异有统计学意义(χ2=34.84,P<0.05)。进一步分层分析,TSH异常者中,甲亢与甲减组TPO-Ab阳性率的比较组间差异无统计学意义(χ2=0.043,P>0.05)。结论葫芦岛地区育龄期女性甲状腺功能异常率较高,应对孕产妇常规进行甲状腺功能检测。
Objective To investigate the significance of thyroid function level and thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase antibody (TPO-Ab) screening in pregnant women of childbearing age in prenatal and postnatal care in prenatal and postnatal life in Huludao. Methods A total of 1 540 cases of women of childbearing age in Huludao City were enrolled. Serum TSH, free thyroxine (FT4), free triiodothyronine (FT3) and TPO-Ab were detected by Roche electrochemiluminescence. Results Of the 5405 women of childbearing age, TSH was abnormal in 135 cases with a total abnormal rate of 8.7%. There was significant difference in TSH abnormalities among different age groups (χ2 = 33.56, P <0.05). The positive rate of TPO-Ab was 8.2%. The difference between TSH normal group and abnormal group was statistically significant (χ2 = 34.84, P <0.05). Further stratified analysis showed that there was no significant difference in the positive rates of TPO-Ab between hyperthyroidism and hypothyroidism among TSH patients (χ2 = 0.043, P> 0.05). Conclusion The female patients of childbearing age in Huludao area have a high rate of abnormal thyroid function, so pregnant women should routinely conduct thyroid function tests.