【摘 要】
：
NRBF2 has been identified as the fifth component of PI3KC3 complex and is required for maintaining the kinase activity to promote autophagy. However, the physiological and pathological roles of NRBF2 are largely unknown. In our recent studies, we have rev
【机 构】
：
State Key Laboratory of Quality Research inChinese Medicine,Institute of Chinese Medical Sciences,Un
论文部分内容阅读
NRBF2 has been identified as the fifth component of PI3KC3 complex and is required for maintaining the kinase activity to promote autophagy. However, the physiological and pathological roles of NRBF2 are largely unknown. In our recent studies, we have revealed that NRBF2 plays an important role in preventing the Alzheimer\'s disease (AD) and inflammatory bowel disease (IBD) development, via the mechanisms involving regulating autophagosome maturation and phagosome maturation. The findings expand our understanding towards the physiological role of PI3KC3 complex and provide a potential strategy for AD and IBD treatment by regulating PI3KC3 complex activity.
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