[目的]重视环孢素的神经毒性,警惕周围神经病肌萎缩。[方法]报告1例重型再障服用环孢素后出现周围神经病。观察减环孢素前后症状变化。[结果]环孢素减量后,通过中西医结合治疗肢体抖动、麻木减轻,肌萎缩仍在加重。停药2个月肌萎缩开始好转。[结论]环孢素导致周围神经病,且与感觉神经症状呈正相关。 [Objective] To emphasize the neurotoxicity of cyclosporine and to guard against peripheral neuropathy muscle atrophy. [Method] A peripheral neuropathy was reported in 1 case of severe aplastic anemia after taking cyclosporine. Observed before and after reduction of cyclosporine symptoms. [Results] Cyclosporine reduced, through the combination of traditional Chinese and Western medicine treatment of limb jitter, numbness, muscle atrophy is still aggravating. Muscle atrophy started 2 months after discontinuation. [Conclusion] Cyclosporine causes peripheral neuropathy and has a positive correlation with sensory neurological symptoms.