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目的:探讨桦树皮抗肿瘤作用及其作用机制。方法:应用桦树皮提取物(EBB)口服观察其对小鼠不同肿瘤的抑制作用。免疫功能检测的方法为胸腺(脾)指数的测定及脾细胞对ConA刺激的反应性和NK细胞活性的测定。结果:EBB抑制小鼠S_(180)、B_(16)黑色素瘤和 Lewis肺癌的生长;并能延长S_(180)和EAS腹水癌小鼠生存期;EBB还可使荷瘤小鼠胸腺(脾)指数增大及增强荷瘤鼠脾细胞对ConA刺激的反应性和NK细胞的活性。结论:桦树皮提取物具有抑制肿瘤细胞的生长、增强机体免疫功能的作用。
Objective: To investigate the anti-tumor effect of birch bark and its mechanism of action. METHODS: The inhibitory effect of birch bark extract (EBB) on different tumors of mice was observed. Methods for the detection of immune function are the measurement of thymus (spleen) index and the determination of splenocyte responsiveness to ConA stimulation and NK cell activity. RESULTS: EBB inhibited the growth of S 180 and B 16 melanoma and Lewis lung carcinoma in mice, and prolonged the survival of mice with S 180 and EAS ascites carcinoma. EBB can also make tumor-bearing mice thymus The exponential increase and enhancement of the reactivity of splenocytes of tumor-bearing mice to ConA stimulation and NK cell activity. Conclusion: The birch bark extract has the function of inhibiting the growth of tumor cells and enhancing the immune function of the body.