血管生成是肿瘤生长与转移的关键基础。本文就泌尿系肾癌、前列腺癌和膀胱癌的血管生成通路与标记物的研究进展加以综述。研究证据表明血管生成标记物和血管因子表达与肿瘤的不良预后相关联。尽管已知血管因子多达50余种,但正在研究的血管生成通路及其抑制机制却几乎很少,其失败原因大多是规模小,缺少相应的统计学分析。不过, Angiogenesis is a key basis for tumor growth and metastasis. This article reviews the progress of angiogenic pathways and markers of urinary renal cancer, prostate cancer and bladder cancer. Research evidence suggests that angiogenic markers and vascular factor expression are associated with poor prognosis of the tumor. Although there are more than 50 known vascular factors, the pathways and mechanisms of angiogenesis that are under study are few, most of which are due to their small scale and lack of corresponding statistical analysis. but,