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于八十年代初开始进行的一系列紫杉醇Ⅰ期临床研究显露出本品所具主要毒性,在大多数研究项目中,当用药剂量由低于150mg/m~2增至190mg/m~2以上时,中性白细胞严重减少现象亦成比例增长,临床中当持续以高于190mg/m~2剂量采用24小时缓慢静滴方案用药时,神经毒性(主要为外周神经病变)为主要毒副作用,研究发现,肌痛、腹泻、脱发、粘膜炎及肝脏毒性等均与用药剂量相关,而过敏反应及心脏毒性的发生则与此无关,目前临床研究虽已探明上述用药剂量与
A series of paclitaxel phase I clinical studies that began in the early 1980s revealed the main toxicities of this product. In most research projects, when the dose was increased from less than 150mg/m2 to 190mg/m2 or more. At the same time, the severe reduction of neutrophils also increased proportionately. When clinically using a slow intravenous infusion regimen of more than 190mg/m~2 for 24 hours, neurotoxicity (mainly peripheral neuropathy) is the main toxic side effect. Studies have found that myalgia, diarrhea, hair loss, mucositis, and hepatotoxicity are all related to the dosage, and the allergic reaction and cardiotoxicity have nothing to do with it. Although the clinical studies have proved the dosage and