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目的观察实验性急性肝损伤对血清有机磷酸酯酶的影响。方法用１０％Ｄ＿氨基半乳糖盐酸盐１次腹腔注射，诱发Ｗｉｓｔａｒ大鼠急性肝坏死；另施手术结扎胆道诱发ＳＤ大鼠胆汁淤积。采尾血测定血清有机磷酸酯酶（ＰＥ）、磷酸二酯酶Ｉ（ＰＤＥＩ）等。结果大鼠急性肝坏死或胆道结扎早期均可见血清ＡＬＴ、碱性磷酸酶（ＡＬＰ）和ＰＤＥＩ活性增高。血清ＰＥ活性无变化。结论血清ＰＥ活性不受急性肝损伤的影响
Objective To observe the effect of experimental acute liver injury on serum organic phosphatase. Methods Acute hepatic necrosis of Wistar rats was induced by intraperitoneal injection of 10% D-galactosamine hydrochloride once. Ligation of the bile duct was also performed to induce cholestasis in SD rats. Tail blood was measured serum organic phosphatase (PE), phosphodiesterase I (PDEI) and so on. Results Serum ALT, alkaline phosphatase (ALP) and PDEI were all increased in acute hepatic necrosis or early biliary ligation in rats. No change in serum PE activity. Conclusion Serum PE activity is not affected by acute liver injury