论文部分内容阅读
盐酸丁萘芬(butenafine hydrochloride,KP-363),化学结构为 N-对-叔丁基苄基-N-甲基-l-萘甲胺盐酸盐。在筛选抗真菌药的研究中发现,双-(萘甲基)胺类抗真菌活性强于克霉唑,构效关系也提示苄胺化合物具有很强的抗真菌活性。萘甲胺类衍生物的
Butenafine hydrochloride (KP-363) has a chemical structure of N-p-tert-butylbenzyl-N-methyl-l-naphthalenemethanamine hydrochloride. In the screening of antifungal agents, bis (naphthylmethyl) amine antifungal activity was stronger than that of clotrimazole, and the structure-activity relationship also suggested that benzylamine compounds have strong antifungal activity. Naphthalene methylamine derivatives