Objective: To evaluate the effect of modified Banxia Xiexin Tang (半夏泻心汤 Pinellia Decoction for Draining the Heart) in treatment of laryngopharyngitis caused by gastroesophageal reflux disease (GERD).Methods: Forty patients in the treatment group were treated with modified Pinellia Decoction for Draining Good Voice by Relieving Sore-Throat). The effects were evaluated by the improvement in symptoms and the parameters obtained in a grading system of gastroscopy and laryngoscopy. Results and Conclusion:The comparison of therapeutic effects on complication of laryngopharyngitis, GERD symptoms, and findings in gastroscope grading and laryngoscope (P＜0.05 or P＜0.01) demonstrated that the modified Pinellia Decoction for Draining the Heart was much more effective in treating laryngopahryngitis caused by gastroesophageal reflux.