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目的探讨缺氧诱导因子-1a(HIF-1a)、血管内皮生长因子(VEGF)、微血管密度(MVD)与子宫内膜癌发生发展的关系。方法采用免疫组织化学方法检测40例子宫内膜癌、22例子宫内膜复杂性增生和18例子宫内膜单纯性增生组织HIF-1a、VEGF及MVD的表达情况。结果①HIF-1a、VEGF、MVD在子宫内膜单纯性增生、复杂性增生及癌组织中的阳性表达率均依次升高,三者比较差异有统计学意义(P<0.01)。②子宫内膜癌中HIF-1a与VEGF、MVD的表达有相关性(P<0.01),且VEGF与MVD的表达也具相关性(P<0.01)。结论HIF-1a、VEGF及MVD在子宫内膜癌的发生、发展中起重要作用,HIF-1a在子宫内膜癌组织中呈高表达,并通过VEGF表达促进肿瘤血管形成。
Objective To investigate the relationship between hypoxia inducible factor-1a (HIF-1a), vascular endothelial growth factor (VEGF), microvessel density (MVD) and the development of endometrial carcinoma. Methods Immunohistochemistry was used to detect the expression of HIF-1a, VEGF and MVD in 40 cases of endometrial carcinoma, 22 cases of endometrial hyperplasia and 18 cases of endometrial hyperplasia. Results ① The positive expression rates of HIF-1a, VEGF and MVD in simple endometrial hyperplasia and complex hyperplasia as well as in cancerous tissues were successively increased, with significant difference between the three groups (P <0.01). ② The expression of HIF-1a in endometrial carcinoma was correlated with the expression of VEGF and MVD (P <0.01), and the expression of VEGF and MVD was also correlated (P <0.01). Conclusions HIF-1a, VEGF and MVD play an important role in the carcinogenesis and progression of endometrial carcinoma. HIF-1a is highly expressed in endometrial carcinoma and promotes tumor angiogenesis through VEGF expression.