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目的:通过分析胎儿脐带血与羊水内IL-18浓度与早产的关系以探讨宫内感染孕期防治的可能性。方法:采集早产(>30周)者和足月分娩孕产妇外周血、脐带血、羊水标本各50例,分别检测其中IL-18的浓度。结果:早产孕妇外周血、羊水、脐带血中IL-18表达水平均高于足月分娩孕妇,且感染患儿脐带血中IL-18浓度则会异常增高。结论:羊水、脐带血中IL-18水平对妊娠的结局有一定的预测性,为预防、阻止早产开辟了一个新途径。同时对新生儿感染性疾病的早治疗提供了科学的数据,有助于临床诊疗水平的提高。
Objective: To analyze the relationship between fetal cord blood and amniotic fluid concentration of IL-18 and preterm delivery to explore the possibility of intrauterine infection prevention during pregnancy. Methods: Peripheral blood, umbilical cord blood and amniotic fluid samples of 50 pregnant women with preterm delivery (> 30 weeks) and full term delivery were collected for detecting the concentration of IL-18. Results: The expression level of IL-18 in peripheral blood, amniotic fluid and umbilical cord blood of premature pregnant women was higher than that of full-term pregnant women, and the level of IL-18 in umbilical cord blood of the infected children was abnormally increased. Conclusion: The levels of IL-18 in amniotic fluid and umbilical cord blood have certain predictive value for the outcome of pregnancy, which opens up a new way to prevent and prevent preterm birth. At the same time, it provides scientific data for the early treatment of neonatal infectious diseases and helps to improve the clinical diagnosis and treatment.