论文部分内容阅读
小鼠在受孕第９～１５天给予氯化镉灌胃，剂量分别为０，１．０，１０．０ｍｇ／ｋｇ，检测其仔鼠在４和８周龄对各项免疫功能的变化。结果发现，从时间上来看，仔鼠外周血白细胞总数、Ｔ淋巴细胞计数和血清溶血素滴度在８周龄时低剂量组有刺激作用，在４周龄时均无影响，表现出迟发作用；从剂量上看，８周龄时上述指标均为低剂量有刺激作用，高剂量无影响。而血清溶菌酶是在４周龄时高剂量组有抑制趋势。母鼠产后２１天肝肾内有明显的镉蓄积，仔鼠胸腺、脾、肝、肾中却未见明显镉蓄积，说明镉对仔鼠免疫功能的影响不是直接作用所致
Mice were given intragastric administration of cadmium chloride on the 9th to 15th day of pregnancy. The doses were 0, 1.0 and 10.0 mg / kg, respectively. The immune function of the offspring mice at 4 and 8 weeks of age was tested. The results showed that, from the time point of view, offspring peripheral white blood cell count, T lymphocyte count and serum hemolysin titers in the 8-week-old low-dose group had a stimulating effect at 4 weeks of age had no effect, showed delayed From the dose point of view, the above indicators at 8 weeks of age are stimulating effects of low doses, high doses have no effect. Serum lysozyme in the 4-week-old high-dose group inhibited the trend. There was a significant accumulation of cadmium in the liver and kidneys of maternal mice 21 days after birth, and no obvious accumulation of cadmium in the thymus, spleen, liver and kidney of the offspring, indicating that cadmium has no direct effect on the immune function of the offspring