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外周神经损伤后在损伤区局部可形成异位离子通道,发现这些离子通道经历着从发生、发展到消失的动态变化过程.神经损伤后的前3d内,损伤区局部首先形成机械敏感通道,这种通道的活动受Ca通道调制.随着神经损伤区K通道的形成和发育,它的敏感性逐渐降低;异位K离子通道约从损伤后第3d出现,通常在术后的7～10d内对其通道阻断剂四乙胺(TEA)的反应最为敏感,这种反应可以维持到术后50d以至更长.神经损伤后异位机械敏感通道与K通道的形成、发育和衰退在时程上具有先后顺序和互换关系.
After peripheral nerve injury, heterotopic ion channels could be formed locally in the injured area, and found that these ion channels undergo dynamic changes from occurrence, development to disappearance. Within the first 3 days after nerve injury, mechanically sensitive channels were formed locally in the injured area The activity of the kind of channel was modulated by Ca channel.With the formation and development of K channel in the nerve injury area, its sensitivity decreased gradually.The ectopic K ion channel appeared about 3 days after injury, usually within 7-10 days Its response to tetrazolium (TEA), the channel blocker, was the most sensitive, and this reaction could be maintained for 50 days or more after operation. The formation, development and decline of ectopic mechanical sensitive channel and K channel after nerve injury were observed in time course On the order and the exchange of relations.