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目的 :分析西宁地区及周边八县 (海拔 2 0 0 0m～ 2 5 0 0m)慢性胃炎发病特点及高原低氧对胃粘膜的损害作用。方法 :选取 6 5例我院胃镜室行胃镜检查的CG病人及活组织送病理学检查 ,分析内镜诊断和病理学诊断 ,并以问卷形式调查其生活状况资料。结果 :内镜诊断CSG 4 3例 ,绝大部分病理学诊断为CAG(76 .74 % ) ,其中近一半伴有肠上皮化生、不典型增生及淋巴滤泡形成等癌前病变 ;内镜诊断CAG 2 1例 ,病理学诊断绝大部分为较重的CAG ,且伴有较重的上述病变。结论 :青海地区慢性胃炎较重 ,可能与高原低氧环境下一氧化氮 (NO)水平降低和内皮素 (ET)水平增高 ,影响胃粘膜微循环血流量有关。
OBJECTIVE: To analyze the characteristics of chronic gastritis and the damage of gastric mucosa caused by plateau hypoxia in eight counties (elevation 200 ~ 2500m) in Xining and surrounding areas. Methods: Sixty-five CG patients and biopsies from our hospital gastroscopy were enrolled in the pathological examination. The endoscopic diagnosis and pathological diagnosis were analyzed. The living conditions of the patients were investigated by questionnaire. Results: Endoscopic diagnosis of CSG 4 cases, the vast majority of pathological diagnosis of CAG (76.74%), of which nearly half associated with intestinal metaplasia, dysplasia and lymphoid follicles and other precancerous lesions; endoscopic Diagnosis of CAG 2 1 cases, the vast majority of pathological diagnosis of severe CAG, and accompanied by heavier lesions. Conclusion: Chronic gastritis is more severe in Qinghai area, which may be related to the decrease of nitric oxide (NO) level and the increase of endothelin (ET) level in the hypoxia environment and the gastric mucosal microcirculation blood flow.