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目的：检测颅内出血患儿脑脊液和血清髓鞘碱性蛋白（ＭＢＰ）的含量，探讨本病脑损害和ＭＢＰ含量变化的关系。方法：采用简易 ＭＢＰ ＥＬＩＳＡ法对３８例脑实质（或伴腔室）出血及腔室内（硬膜下腔、蛛网膜下腔、脑室）出血患儿脑脊液和血清标本作 ＭＢＰ定量测定，与对照组比较，并于治疗 ４－５周后复查对比。结果：两出血组脑脊液和血清 ＭＢＰ的含量明显高于对照组（Ｐ均＜０．０１），有脑实质出血组脑脊液和血清 ＭＢＰ含量亦高于腔室内出血组（Ｐ＜０．０１），治疗后ＭＢ Ｐ含量未见下降。结论：脑脊液和血清ＭＢＰ定量测定作为生化方面的指标丰富了本病诊断的实验室检查内容，有助于本病的预后评估。
Objective: To detect the levels of cerebrospinal fluid and serum myelin basic protein (MBP) in children with intracranial hemorrhage and to explore the relationship between the brain damage and MBP content in this disease. Methods: The MBP ELISA method was used to determine the MBP levels in cerebrospinal fluid (CSF) and serum of 38 patients with hemorrhagic or parenchymal hemorrhage and intracerebroventricular (subdural, subarachnoid and intracerebral) hemorrhage. Compared with the control group Comparison, and in the treatment of 4-5 weeks after the review comparison. Results: The levels of cerebrospinal fluid (CSF) and serum MBP in two bleeding groups were significantly higher than those in control group (all P <0.01). Cerebrospinal fluid (MBP) and serum MBP in patients with intracerebral hemorrhage were also significantly higher than those in intracerebral hemorrhage (P <0.01) After treatment MB P content no decline. Conclusion: The quantitative determination of cerebrospinal fluid and serum MBP as a biochemical indicators enriched the contents of the laboratory diagnosis of the disease, contribute to the prognosis of the disease.