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用单克隆抗体-抗原斑点试验(McAb-AST)又一次对30例黑热病患者作血清循环抗原检测,以研究对疗效考核的价值,其中5例作了治疗前和治疗后的比较,血清循环抗原转为阴性反应者一例,由强阳性转为中度阳性及持续呈阳性者各2例,均与患者临床表现及原虫查获情况吻合。另25例经锑剂一疗程后一年左右用本法测检,13例呈阴性,12例呈中度或弱阳性反应。251例正常人及结核等传染病患者均呈阴性,无假阳性出现。说明本法特异、敏感,并进一步证实了对黑热病的疗效考核有价值,且方法简易可行,易为病人接受。提示可望取代骨髓涂片检查。
Serum circulating antigens were also tested in 30 patients with kala-azar by monoclonal antibody-antigen spot test (McAb-AST) in order to study the value of the efficacy evaluation. Five of them were compared before and after treatment. Serum circulating antigens A case of negative reaction turned from strong positive to moderate positive and persistent positive in 2 cases, both with clinical manifestations and parasite seizures consistent. Another 25 cases of antimony agent after a course of about one year using this test, 13 were negative, 12 were moderate or weak positive reaction. 251 cases of normal and tuberculosis and other infectious diseases were negative, no false positive. This method is peculiar and sensitive. It further confirms the value of the curative effect assessment on kala-azar, and the method is simple and feasible and is easy for patients to accept. Tip is expected to replace the bone marrow smear test.