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目的 探讨脑血管血液动力学指标 (CVHI)和其他脑卒中危险因素与脑卒中发病风险的关系。方法 以整群抽样的方法选择东北、华北等六大行政区 35岁及以上的队列人群 2 5 355人 ,进行脑卒中常见危险因素的基线调查 ,同时进行CVHI检测 ,并对检测结果进行积分。随访 7年中共发生脑卒中患者 2 2 8例 ,以脑卒中的发病作为观察终点 ,按危险因素暴露和CVHI积分分组 ,计算暴露与否发病的相对危险度 (RR)及其可信区间 (CI) ,并用Cox回归进行多因素分析。结果 单因素分析显示 :高血压、心脏病、糖尿病、高血压病家族史、脑卒中家族史、超重或肥胖、饮酒史、吸烟史、CVHI积分 <75分的RR值分别为 3 .2 3(2 .48～ 4 .2 0 )、2 .53(1 .92～ 3 .33)、2 .38(1 .55～ 3 .64)、1 .32(1 .0 2～ 1 .72 )、1 .82 (1 .37～ 2 .41 )、1 .62 (1 .2 5～ 2 .1 1 )、1 .48(1 .0 7～ 2 .0 4 )、1 .76(1 .34～ 2 .31 )和 7.30(5 .43～ 9.80 ) ;多因素Cox回归分析显示 :被筛选进入回归方程的因素分别为 :CVHI积分异常、脑卒中家族史、吸烟、高血压病史、年龄和性别 ;CVHI积分的剂量反应关系分析显示 ,脑卒中的风险随着CVHI的积分降低而显著上升 ;协同作用分析显示 ,当CVHI积分 <75分和高血压合并出现时 ,脑卒中的RR值为 1 2 .55 ,表现?
Objective To investigate the relationship between cerebrovascular hemodynamic parameters (CVHI) and other stroke risk factors and the risk of stroke. Methods A total of 2555 cohorts aged 35 and over in Northeast China and North China were enrolled in this study. Baseline surveys of common risk factors for stroke were performed. CVHI test was performed and the test results were integrated. During the follow-up of 7 years, a total of 228 stroke patients were enrolled in this study. The incidence of stroke was taken as the end point of the study. Risk exposure and CVHI were used to calculate the relative risk (RR) and its confidence interval (CI) ) And multivariate analysis using Cox regression. Results Univariate analysis showed that the RR of hypertension, heart disease, diabetes, family history of hypertension, family history of stroke, overweight or obesity, alcohol drinking history, smoking history and CVHI <75 were 3.23 2 .48 ~ 4 .2 0), 2.53 (1.92 ~ 3.33), 2.38 (1.55 ~ 3.64), 1.32 (10.2 ~ 1.72), 1 .82 (1 .37 ~ 2 .41), 1.62 (1 .2 5 ~ 2 .1 1), 1 .48 (1 .0 7 ~ 2 .0 4), 1 .76 (1 .34 ~ 2.31) and 7.30 (5.43 ~ 9.80). The multivariate Cox regression analysis showed that the factors that were screened into the regression equation were CVHI score, family history of stroke, smoking, history of hypertension, age and gender ; CVHI integral dose response relationship analysis showed that the risk of stroke with the CVHI decreased significantly decreased; synergy analysis showed that when the CVHI score <75 points and hypertension associated with stroke, the RR was 12 .55, performance?