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目的:评价初诊上皮性卵巢癌患者血清CA-125水平与其预后的关系。方法:回顾性分析145例初诊上皮性卵巢癌患者血清CA-125水平与FIGO分期、肿瘤细胞分化程度的关系。采用Kaplan-Meier生存曲线分析初诊患者血清CA-125水平与其远期预后的关系,并利用Cox风险比例模型分析血清CA-125水平与患者远期预后的独立相关性。结果:初诊卵巢癌患者血清CA-125水平随着FIGO分期的增加而逐渐增高,随着肿瘤细胞分化程度的增加而逐渐降低。血清CA-125≤194.10kU/L的患者,其远期预后优于血清CA-125>194.10kU/L。Cox风险比例模型表明,在校正了年龄,FIGO分期,肿瘤细胞分化程度等因素后,血清CA-125水平增高(>194.10kU/L)与患者远期预后的风险比为1.750(95%CI:1.1053～2.773)。结论:血清CA-125水平是上皮性卵巢癌患者预后的独立危险因子。
Objective: To evaluate the relationship between serum CA-125 levels and prognosis in newly diagnosed epithelial ovarian cancer patients. Methods: A retrospective analysis of 145 cases of newly diagnosed epithelial ovarian cancer patients with serum CA-125 levels and FIGO stage, the relationship between tumor cell differentiation. Kaplan-Meier survival curves were used to analyze the relationship between the serum CA-125 level and the long-term prognosis of newly diagnosed patients. Cox proportional hazards model was used to analyze the independent correlation between serum CA-125 level and long-term prognosis. Results: The serum level of CA-125 in patients with newly diagnosed ovarian cancer increased gradually with the increase of FIGO staging, and gradually decreased with the increase of tumor cell differentiation. The long-term prognosis of patients with serum CA-125≤194.10kU / L is superior to that of serum CA-125> 194.10kU / L. Cox proportional hazards model showed that after adjusting for age, FIGO stage, tumor cell differentiation and other factors, the risk ratio of serum CA-125 level (> 194.10kU / L) to the long-term prognosis was 1.750 (95% CI: 1.1053 ~ 2.773). Conclusion: Serum CA-125 level is an independent risk factor for prognosis in patients with epithelial ovarian cancer.