2013年5月6日,美国食品药品管理局(FDA)向医务人员和女性发布安全警告:孕妇禁用丙戊酸、丙戊酸钠、双丙戊酸钠预防偏头痛~([1])。近期的研究发现,孕妇在妊娠期间服用这些药物,会导致儿童智商下降~([2])。该警告信息将被添加到药物说明书中,此外,丙戊酸类药物用于偏头痛的妊娠用药等级也将由原来的“D”级调整为“X”级。丙戊酸类药物包括丙戊酸钠、双丙戊酸钠、丙戊酸及其仿制品,临床用于治疗某些类型的癫痫、伴有双相情感障碍的躁狂发作等精神疾病以及预防偏头痛。一项调查显示,2012年美国使用丙戊酸类药物的育龄女性中约57%被诊断为情感障碍,10%为精神分裂症,9%为偏头痛,9%为癫痫。此警告是FDA基于一项关于抗癫痫药物对神经发育影 On May 6, 2013, the U.S. Food and Drug Administration (FDA) issued a safety alert to healthcare workers and females: Valproic acid, sodium valproate and divalproex are forbidden in pregnant women to prevent migraines (1). Recent studies have found that taking these medications during pregnancy in pregnant women can lead to a drop in IQ in children ~ ([2]). The warning message will be added to the drug’s instructions. In addition, the medication grade of valproate for migraine will also be adjusted from the original “D” level to the “X” level. Valproic acid drugs include sodium valproate, divalproex, valproic acid and their replicas, clinical disorders used to treat certain types of epilepsy, manic episodes with bipolar disorder, and prophylaxis Migraine. According to one survey, about 57% of women of reproductive age who used valproate in the United States in 2012 were diagnosed with affective disorder, 10% were schizophrenia, 9% were migraine, and 9% were epilepsy. This warning is based on an FDA’s anti-epileptic drugs on neurodevelopmental effects