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目的探讨注射用果糖二磷酸镁粉针剂的安全性。方法通过对果糖二磷酸镁粉针剂过敏性作用、降压物质、热原及溶血作用,评价果糖二磷酸镁粉针剂的安全性。结果豚鼠隔日im果糖二磷酸镁5mg/0.5ml/只,未出现过敏反应;猫iv果糖二磷酸镁10mg/0.2ml/kg,降压物质检查结果为阴性;家兔耳静脉注射60mg/kg,连续观察3小时,热原检查结果为阴性;1mg/ml果糖二磷酸镁溶液对兔红细胞没有溶血和凝聚作用。结论注射用果糖二磷酸镁粉针剂用于静脉给药安全可靠。
Objective To investigate the safety of injection of magnesium fructose magnesium phosphate injection. Methods The safety of magnesium fructose diphosphate injection was evaluated through the allergic effects of magnesium fructose diphosphate injection, hypotensive substances, pyrogen and hemolysis. Results Guinea pig every other day im fructose magnesium diphosphate 5mg / 0.5ml / only, no allergic reaction; cat iv magnesium fructose diphosphate 10mg / 0.2ml / kg, blood pressure test results were negative; rabbit ear intravenous injection of 60mg / kg, Continuous observation of 3 hours, pyrogen test results were negative; 1mg / ml fructose magnesium diphosphate solution on rabbit erythrocytes without hemolysis and aggregation. Conclusion Injection of fructose magnesium diphosphate injection is safe and reliable for intravenous administration.