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新生儿同种免疫性血小板减小性紫癜(NAITP)的早期诊断,须在母亲妊娠期筛查 IgG 抗血小板抗体,国内尚较少见这方面的报道,本文对我院2110倒产妇,在妊娠期作 IgG 血小板抗体血清学筛查,抗体阳性率为2.2%(46/2110),母亲抗体效价在1:2-1:64之间。对抗体阳性者,其所生的婴儿中35例于生后3天内,得到追踪,查婴儿血红蛋白、血小板及观察婴儿临床表现。结果,这35例婴儿中有4例发生出血性皮肤紫癜(11.4%),3例婴儿血红蛋白低,占35例的8.6%。血小板计数<100×10~9/L 有8例(22.9%),8例中3例发生皮下出血(37.5%)。出血婴儿其母亲的抗血小板抗体效价均在1:8-1:16之间.说明抗体效价在1:8时就能引起婴儿出血症状,所以早期发现是至为重要。
Neonatal alloimmune thrombocytopenic purpura (NAITP) of the early diagnosis, the mother should be IgG screening during pregnancy anti-platelet antibodies, is still relatively rare in this regard reported in our hospital 2110 inverted maternal, pregnancy Serum screening for IgG platelet antibodies was performed, with the antibody positive rate of 2.2% (46/2110) and the maternal antibody titer of 1: 2-1: 64. Antibody-positive, the birth of 35 babies born within 3 days after being tracked, check the baby’s hemoglobin, platelets and observe the clinical manifestations of infants. As a result, hemorrhagic cutaneous purpura (11.4%) occurred in 4 of these 35 infants and low infantile hemoglobin in 3 infants (8.6% of 35). Eight patients (22.9%) had platelet counts <100 × 10 ~ 9 / L, and 3 patients developed subcutaneous hemorrhage (37.5%) in 8 patients. Bleeding baby mothers anti-platelet antibody titers are between 1: 8-1: 16. That the antibody titer at 1: 8 can cause baby bleeding symptoms, so early detection is of paramount importance.