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A series of new hexahydroimidazo[1,2-α]pyridine derivatives were synthesized via convenient and practical three-component reactions.Preliminary bioassays showed that majority of the target compounds exhibited moderate to excellent insecticidal activity against cowpea aphids(Aphis craccivora).Among them,compound 91 demonstrated significant activity with LC_(50) value of0.00918 mmol/L which was about 3.8-fold higher than that of imidacloprid(IMI).Furthermore,the study of stereostructure-activity relationship of four isomers of 9k indicated that configuration played a key role in insecticidal activity of these compounds.
A series of new hexahydroimidazo [1,2-α] pyridine derivatives were convenient and practical three-component reactions. Preliminary bioassays showed that majority of the target compounds showed moderate to excellent insecticidal activity against cowpea aphids (Aphis craccivora) .Among them , compound 91 demonstrated significant activity with LC 50 value of 0.00918 mmol / L which was about 3.8-fold higher than that of imidacloprid (IMI). Stillrther, the study of stereostructure-activity relationship of four isomers of 9k indicated that configuration played a key role in insecticidal activity of these compounds.