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目的:比较宫颈环形电切术(LEEP)和宫颈冷刀锥切术(CKC)治疗宫颈上皮内瘤样病变(CIN)的临床效果。方法:选取2005年11月～2009年8月在江西省赣州市妇幼保健院宫颈疾病门诊就诊的CIN患者198例,随机分成两组,观察组应用高频环形电刀行宫颈锥切术,对照组采用冷刀行宫颈锥切术,观察手术时间、术中出血量、手术费用、术后并发症、术后效果等。结果:手术时间、术中出血量、手术费用CKC组高于LEEP组,差异有高度统计学意义(P<0.01);术后并发症两组比较,差异无统计学意义(P>0.05);术后病灶残留率、病变复发率比较,差异无统计学意义(P>0.05)。结论:宫颈环形电切术治疗宫颈CIN简单、安全、有效、出血少,术后宫颈恢复好,由于手术后少部分患者仍然有病变持续存在且复发可能,所以治疗后应密切随访。
Objective: To compare the clinical effects of cervical ring resection (LEEP) and cervical cold knife conization (CKC) in the treatment of cervical intraepithelial neoplasia (CIN). Methods: A total of 198 CIN patients were selected from the Department of Cervical Disease Clinic of Ganzhou MCH Hospital of Jiangxi Province from November 2005 to August 2009, and randomly divided into two groups. The observation group was treated by high frequency electrosurgical knife cervical conization, Group using cold knife cervical conization, observation of operative time, intraoperative blood loss, surgical costs, postoperative complications, postoperative effects. Results: The operation time, intraoperative blood loss and operation cost were higher in CKC group than in LEEP group (P <0.01). There was no significant difference in postoperative complications between the two groups (P> 0.05). Postoperative lesion residual rate, lesion recurrence rate, the difference was not statistically significant (P> 0.05). Conclusion: CIN is a simple, safe and effective method for the treatment of cervical CIN. It has less bleeding and better cervical recovery. Because of the persistence and recurrence of the lesion in some patients after operation, the CIN should be closely followed up.