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目的：探讨ＣＤ２８及ＣＤ８０分子在活跃期ＳＬＥ患者外周血单个核细胞（ＰＢＭＣ）上的表达及在ＳＬＥ发病中的可能作用机制。方法：采用流式细胞仪检测 １３例初发活跃期及 １３例复发活跃期 ＳＬＥ患者ＰＢＭＣ表面 ＣＤ２８及ＣＤ８０分子的表达。结果：初发及复发活跃期ＳＬＥ患者ＰＢＭＣ表达ＣＤ２８分子与正常对照组比较有一定程度的下降，但差异无显著性（Ｐ＞０．０５）。初发活跃期ＳＬＥ患者ＰＢＭＣ表达ＣＤ８０分子较正常对照组明显升高（Ｐ＜０．０５）。初发与复发活跃期ＳＬＥ患者之间比较ＰＢＭＣ表达ＣＤ２８及ＣＤ８０分子无显著性差异（Ｐ＞０．０５）。结论：ＳＬＥ患者外周血Ｔ细胞及ＡＰＣ间存在异常的ＣＤ２８－ＣＤ８０。共刺激分子的信号传导，这种异常的信号传导在ＳＬＥ发病机制中可能起着重要的作用。
Objective: To investigate the expression of CD28 and CD80 on peripheral blood mononuclear cells (PBMCs) in patients with active SLE and the possible mechanism of them in the pathogenesis of SLE. Methods: Flow cytometry was used to detect the expression of CD28 and CD80 on the surface of PBMC in 13 primary SLE patients and 13 relapsed active patients. Results: The expression of CD28 in peripheral blood mononuclear cells of primary and recurrent active SLE patients decreased to a certain extent compared with that of normal controls, but the difference was not significant (P> 0.05). The number of CD80 in PBMC of active SLE patients was significantly higher than that of normal controls (P <0.05). There was no significant difference in the expression of CD28 and CD80 in PBMC between primary and relapsed active SLE patients (P> 0.05). Conclusion: There are abnormal CD28-CD80 in peripheral blood T cells and APC in SLE patients. Costimulatory molecules, this abnormal signal transduction may play an important role in the pathogenesis of SLE.