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目的 研究共同性斜视患者眼外肌本体感受器 (extraocularmuscleproprioceptor,EMP)的形态学改变 ,为探讨斜视的发病机制提供依据。方法 取 2 8例共同性斜视患者和 11例眼球摘除者的眼外肌 ,采用Holmes′法染色后在光镜及透射电镜下观察 ,并计算相同放大倍数下每例标本面积40 0 0mm2 的轴突中线粒体个数。结果 光镜下可见位于眼外肌肌 腱连接处的EMP神经纤维终止于邻近单个梭外肌纤维的起始处或两侧 ;电镜下斜视患者EMP与对照组比较 ,结构紊乱 ,神经成分消失 ;每例标本面积 40 0 0mm2 轴突中线粒体个数实验组明显少于对照组 (P <0 0 5 )。结论 斜视患者EMP结构的紊乱 ,导致EMP接收、传递信息功能异常 ,从形态学角度证实了EMP紊乱在共同性斜视发病机制中具有重要作用。
Objective To investigate the morphological changes of extraocular muscle predisposing receptor (EMP) in patients with common strabismus and to provide basis for exploring the pathogenesis of strabismus. Methods The extraocular muscles of 28 cases of common strabismus and 11 cases of enucleation were enrolled in this study. They were observed under light microscope and transmission electron microscope after staining with Holmes’ method, and the axis of 40 000 mm of each specimen under the same magnification Suddenly the number of mitochondria. Results Under light microscope, the EMP nerve fibers located at the tendon junction of the extraocular muscles were terminated at the beginning or both sides of the adjacent single extrafusial muscle fibers. EMP in the strabismus patients under electron microscope was disorganized and the nerve components disappeared. The number of mitochondria in the specimens with an area of 400 mm2 was significantly less in the experimental group than in the control group (P <0.05). Conclusion The disorder of EMP structure in patients with strabismus leads to abnormal EMP receiving and transmitting information. It is confirmed from the morphological point that EMP disorder plays an important role in the pathogenesis of common strabismus.