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目的为了探讨贫血与慢性肾衰（ＣＲＦ）免疫功能状态的关系。方法检测了ＣＲＦ患者单纯输血及用红细胞生成素（ＥＰＯ）治疗前后细胞因子白细胞介素２（ＩＬ２）、可溶性白细胞介素２受体（ｓＩＬ２Ｒ）、肿瘤坏死因子（ＴＮＦ）及γ干扰素（γＩＦＮ）水平，并与肾功能正常肾小球肾炎患者（ＧＮ）组及对照组（Ｃ）进行比较分析。结果ＣＲＦ组血清ＩＬ２，ＴＮＦ和γＩＦＮ水平均显著低于ＧＮ组及Ｃ组（Ｐ＜００１），ｓＩＬ２Ｒ水平则较ＧＮ组及Ｃ组明显升高（Ｐ＜００１）。ＣＲＦ组血清ＩＬ２，ＴＮＦ和γＩＦＮ水平与血红蛋白浓度存在直线正相关，而ｓＩＬ２Ｒ水平与血红蛋白浓度呈负相关性，单纯输血或应用ＥＰＯ治疗能改变这些细胞因子活性水平。结论ＣＲＦ免疫功能低下与贫血有关，及时治疗和改善贫血状态可部分纠正这种免疫异常。
Objective To explore the relationship between anemia and immune function of chronic renal failure (CRF). Methods The levels of interleukin-2, soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor (TNF) in patients with CRF after transfusion and before erythropoietin (EPO) And γ interferon (γIFN) levels, and with renal function in patients with glomerulonephritis (GN) group and control group (C) were analyzed. Results The levels of serum IL-2, TNF and IFN-γ in CRF group were significantly lower than those in GN group and C group (P <001), while the levels of sIL2R in CRF group were significantly higher than those in GN group and C group 01). CRF serum IL 2, TNF and γ IFN levels and hemoglobin concentration there is a linear correlation, and sIL 2R levels and hemoglobin concentration was negatively correlated with transfusion or EPO treatment can change the level of these cytokines. Conclusion The immunocompromised CRF is associated with anemia, and the timely treatment and improvement of anemia may partially correct this immune abnormality.