急性早幼粒细胞白血病(APL)多死于出血,近年来在联合化疗的同时加用肝素治疗,据报道缓解率可达43-60%。本文报道美国纪念医院对APL取得满意疗效方案,以供同行参考,对象为57位患APL未接受治疗或治疗不充分的成年病人,其中男27例,女30例,年龄15-71岁(平均35岁),57例均符合FAB分型的M-3型。本组各例的纤维蛋白原平均含量为130mg/dl,正常值为150-280mg/dl。25例诊断有纤维蛋白升高,23例凝血酶原时间延长,所有病例血小板<100000/μl,且伴皮肤粘膜出血,其中18例有胃肠出血或血尿,24例女性病人有经血过多。方法:(1),Ⅰ组16例(1974-1977年),治疗方案为: Acute promyelocytic leukemia (APL) more deaths from bleeding, combined with chemotherapy in recent years with heparin therapy, reportedly remission rate of up to 43-60%. This article reports that the Memorial Hospital of the United States to obtain a satisfactory curative effect of APL program for peer reference for 57 patients with APL untreated or inadequately treated adult patients, including 27 males and 30 females, aged 15-71 years (mean 35 years old), 57 cases were FAB type M-3 type. Each group of cases of fibrinogen average content of 130mg / dl, the normal value of 150-280mg / dl. Twenty-five patients had fibrinopathies diagnosed, prolonged prothrombin time in 23 patients, platelet count <100 000 / μL in all cases, and skin and mucous membrane hemorrhage. Of these, 18 had gastrointestinal hemorrhage or haematuria and 24 women had excessive menstrual bleeding. Methods: (1), group Ⅰ 16 cases (1974-1977), the treatment plan is: