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本文报告3例大颗粒淋巴细胞增多症伴慢性中性粒细胞减少症患者。本病系脾肿大、中性粒细胞减少、多种自身抗体和大颗粒淋巴细胞增多综合征。通过细胞遗传学、免疫学和功能研究,发现同源细胞遗传异常,淋巴细胞对脾脏红髓、肝窦、骨髓浸润,从而表明这种大颗粒淋巴细胞的白血病性质。
This article reports 3 cases of large granular lymphocytosis with chronic neutropenia patients. The disease is splenomegaly, neutropenia, a variety of autoantibodies and large particle lymphocytosis syndrome. By cytogenetics, immunology and functional studies found that homologous cytogenetic abnormalities, lymphocytes on the spleen red pulp, sinusoids, bone marrow infiltration, thus indicating the large granulocyte lymphocyte leukemia nature.