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目的:探讨脂肪酸合成酶(FASN)在直肠癌患者外周血中的表达变化及意义。方法:选取经病理活检诊断为直肠癌的患者42例,其中28例行直肠癌根治术(根治组),14例行直肠癌姑息术(姑息组),选取正常人16例(对照组);分别应用ELISA方法检测正常人及直肠癌患者手术前后外周血中FASN的浓度。结果:术前直肠癌患者外周血FASN水平明显高于对照组(P<0.05);根治组术后患者血FASN低于术前(P<0.05),与对照组比较无统计学差异(P>0.05),姑息组术后血FASN水平与术前比较无统计学差异(P>0.05),且高于对照组和根治组术后患者(P<0.05);Logistic回归分析表明:癌胚抗原(CEA)、FASN、C反应蛋白(CRP)、便秘史是直肠癌的危险因素(P<0.05)。结论:FASN在直肠癌患者外周血中表达增高,术后患者血FASN水平降低,测定FASN在外周血的表达可能成为早期诊断恶性肿瘤及判断预后的一个重要指标。
Objective: To investigate the changes and significance of fatty acid synthetase (FASN) in peripheral blood of patients with rectal cancer. Methods: Forty - two patients diagnosed as rectal cancer by pathological biopsy were selected. Twenty - eight patients underwent rectal cancer radical surgery (radical group), 14 patients underwent palliative rectal cancer (palliative group) and 16 normal subjects (control group). The concentrations of FASN in peripheral blood of normal and rectal cancer patients before and after operation were detected by ELISA. Results: The FASN level in peripheral blood of patients with preoperative rectal cancer was significantly higher than that of the control group (P <0.05). The FASN of postoperative patients in the radical operation group was lower than that before operation (P <0.05), and there was no significant difference between the two groups (P> 0.05). The level of FASN in palliative group had no significant difference compared with that before operation (P> 0.05), which was higher than that in control group and postoperative group (P <0.05). Logistic regression analysis showed that: CEA), FASN, C-reactive protein (CRP) and constipation were the risk factors of rectal cancer (P <0.05). Conclusion: The expression of FASN is increased in peripheral blood of patients with rectal cancer and the level of FASN in postoperative patients is decreased. To determine the expression of FASN in peripheral blood may be an important index for early diagnosis of malignant tumor and prognosis.