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目的 评价沙丁胺醇气雾剂 (SAL)及溴化异丙托品气雾剂 (IPB)对哮喘患者支气的扩张作用。方法 选择 1 0例轻度—中度哮喘患者按随机交叉方法分别吸入SAL2 0 0ug(A组 )、IPB40mg(B组 )、SAL2 0 0ug +IPB40ug(C组 ) ,相隔 2 4小时。用微型肺功能仪测定吸入前和吸入后 5、30、1 2 0、2 4 0、360、480、60 0分钟的肺功能。结果SAL、IPB吸入后FVC、FBV1 0 、PEF、MMF、FEF50 % 均出现显著改善 (P <0 0 5 )。SAL吸入后 5分钟起效 ,作用持续 4小时 ;IPB吸入后 30分钟起效 ,作用持续 6— 8小时。两药合用起效快 ,作用时间长。结论SAL、IPB对哮喘患者均有支气管扩张作用 ,两药合用优于单独应用
Objective To evaluate the effects of salbutamol aerosol (SAL) and ipratropium bromide aerosol (IPB) on bronchial dilation in asthmatic patients. Methods One hundred and seventy patients with mild to moderate asthma were randomly divided into two groups: SAL 2 0ug (group A), IPB 40mg (group B), SAL 2 0ug + IPB 40ug (group C), separated by 24 hours. Pulmonary function was measured before and after inhalation with a mini-lung function at 5, 30, 120, 240, 360, 480, 60 minutes. Results After treatment with SAL, the FVC, FBV1 0, PEF, MMF and FEF50% significantly improved (P <0 05). SAL 5 minutes after the onset of action, the role of sustained 4 hours; IPB 30 minutes after onset of onset, the role of sustained 6 - 8 hours. Combination of two fast onset, role for a long time. Conclusions Both SAL and IPB have bronchodilation effects in patients with asthma,