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目的了解可溶性肿瘤坏死因子受体I在哮喘患儿发病中的作用。方法用ELISA法对哮喘患儿急性发作组,哮喘缓解组及健康对照组儿童血清可溶性肿瘤坏死因子受体Ⅰ(sTNF-RI)水平进行检测。结果哮喘发作组sTNF-RI浓度为4.91±0.39ng/ml,哮喘缓解组为2.35±0.43ng/ml,明显高于健康对照组(1.26±0.24ng/ml),(P<0.01和P<0.05);哮喘发作组亦高于缓解组(P<0.05)。结论sTNF-RI可能参与了哮喘气道炎症反应的发病过程。
Objective To understand the role of soluble tumor necrosis factor receptor I in the pathogenesis of asthma in children. Methods Serum levels of soluble tumor necrosis factor receptor Ⅰ (sTNF-RI) in acute asthmatic children, asthmatic remission children and controls were detected by ELISA. Results The levels of sTNF-RI in the asthma attack group were 4.91 ± 0.39ng / ml and 2.35 ± 0.43ng / ml in the asthma remission group, which were significantly higher than those in the healthy control group (1.26 ± 0.24ng / ml, P <0.01 and P <0.05) ); Asthma attack group was also higher than remission group (P <0.05). Conclusion sTNF-RI may be involved in the pathogenesis of airway inflammation in asthma.