蒽环类药物如阿霉素、表阿霉素、吡喃阿霉素、柔红霉素及米托蒽醌等,已广泛应用于乳腺癌的辅助治疗中并取得了突出的疗效且奠定了其基石地位[1]。蒽环类的常见不良反应有脱发、骨髓抑制、心脏毒性等。如何选择一种高效、经济、不良反应低的化疗药物备受关注。吡柔比星(pirarubi-cen,THP)是新一代半合成的蒽环类抗肿瘤抗生素,抗肿瘤 Anthracyclines such as doxorubicin, epirubicin, pirarubicin, daunorubicin and mitoxantrone have been widely used in the adjuvant treatment of breast cancer and achieved outstanding efficacy and laid Its cornerstone [1]. Common anthracycline adverse reactions are hair loss, bone marrow suppression, cardiac toxicity. How to choose a high-efficiency, low-cost adverse drug chemotherapy has drawn much attention. Pirarubi-cen (pirarubi-cen, THP) is a new generation of semi-synthetic anthracycline antitumor antibiotics, anti-tumor