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目的观察益气化聚颗粒联合西药治疗代谢综合征微量白蛋白尿的临床疗效。方法将100例代谢综合征微量白蛋白尿症患者随机分为治疗组与对照组,每组50例。治疗组在常规西医治疗基础上加用益气化聚颗粒,对照组在常规西医治疗基础上加用安慰剂。两组疗程均为12周,观察微量白蛋白尿的转阴率,比较尿液相关指标(MA、UACR、24 h TP、尿转铁蛋白及尿β2微球蛋白)、形体体征指标(BMI、WHR、SBP、DBP及MAP)、血糖(FPG、2 h PPG、Hb A1c及HOMA-IR)及血脂(TC、TG、LDL、HDL)的变化情况。结果 1试验期间无脱落病例,100例受试者均完成试验研究。2治疗组、对照组转阴率分别为28.00%和10.00%;组间转阴率比较,差异有统计学意义(P<0.05)。3组间治疗后比较,MA、UACR、24 h TP及尿β2微球蛋白水平差异有统计学意义(P<0.05)。4组间治疗后比较,BMI、WHR、SBP及MAP水平差异有统计学意义(P<0.05)。5组间治疗后比较,FPG、2 h PPG、Hb A1c及HOMAIR水平差异有统计学意义(P<0.05)。6组间治疗后比较,TG水平差异有统计学意义(P<0.05)。结论益气化聚颗粒联合西药治疗代谢综合征微量白蛋白尿,可有效控制疾病的进展,提高胰岛素敏感性,减轻中心性肥胖程度。
Objective To observe the clinical efficacy of Yiqi Huacao granule combined with Western medicine in treating metabolic syndrome microalbuminuria. Methods 100 patients with metabolic syndrome microalbuminuria were randomly divided into treatment group and control group, 50 cases in each group. The treatment group in the conventional Western medical treatment based on the use of Yiqi poly particles, the control group on the basis of conventional Western medicine plus placebo. The course of treatment was 12 weeks. The urinary albuminuria conversion rate was observed. The urinary indexes (MA, UACR, 24 h TP, urinary transferrin and urinary β2 microglobulin), body mass index (BMI, WHR, SBP, DBP and MAP), blood glucose (FPG, 2 h PPG, Hb A1c and HOMA-IR) and blood lipid (TC, TG, LDL, HDL) Results 1 No shedding cases during the trial, 100 subjects completed the pilot study. 2 treatment group, the control group, the negative conversion rates were 28.00% and 10.00%; between groups, the negative conversion rate, the difference was statistically significant (P <0.05). After treatment, MA, UACR, 24 h TP and urine β2 microglobulin levels were significantly different (P <0.05). After treatment, the differences of BMI, WHR, SBP and MAP between the four groups were statistically significant (P <0.05). After treatment, the levels of FPG, 2 h PPG, Hb A1c and HOMAIR in the 5 groups were significantly different (P <0.05). There were significant differences in TG levels between the 6 groups after treatment (P <0.05). Conclusion Yiqi Huagong granules combined with Western medicine in the treatment of metabolic syndrome microalbuminuria can effectively control the disease progression, improve insulin sensitivity and reduce the degree of central obesity.