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用放射免疫法测定49例甲亢患者及30例正常对照组血浆心钠素浓度,发现甲亢患者血浆心钠素浓度明显高于正常对照组(P<0.01),且血浆心钠素浓度与T_3、T_4、γT_3、心率呈正相关,与脉压差无相关。将甲亢患者分为他巴唑及利血平治疗组,结果提示他巴唑治疗组治疗后随着T_3、T_4、γT_3等甲状腺激素水平的下降,心率、心钠素水平也较治疗前显著下降(P<0.01)。利血平组治疗后在心率下降的同时,T_3、T_4、γT_3水平较前轻度增高,血浆心钠素浓度治疗前后变化不大(P>0.05)。
Plasma atrial natriuretic peptide concentrations were measured by radioimmunoassay in 49 patients with hyperthyroidism and 30 normal controls. Plasma atrial natriuretic peptide concentrations in patients with hyperthyroidism were significantly higher than those in normal controls (P <0.01) T_4, γT_3, heart rate was positively correlated, no correlation with pulse pressure. Hyperthyroidism patients were divided into methimazole and reserpine treatment group, the results suggest that metoprolol treatment group with T_3, T_4, γT_3 and other thyroid hormone levels decreased, heart rate, atrial natriuretic peptide levels were significantly lower than before treatment (P <0.01). The levels of T 3, T 4 and γ T 3 were slightly increased before and after treatment in reserpine group. The changes of plasma atrial natriuretic peptide did not change much before and after treatment (P> 0.05).