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目的探讨阿托伐他汀联合二甲双胍对2型糖尿病高脂血症患者血脂及C反应蛋白的影响。方法 138例患者随机分成两组,对照组给予二甲双胍,观察组给予阿托伐他汀和二甲双胍,观察治疗前后血糖、血脂和C反应蛋白水平。结果观察组hs-CRP明显下降,HDL-C明显升高(P<0.05),尤其观察组TC、TG、LDL-C、hs-CRP改善方面优于对照组(P<0.05)。结论阿托伐他汀联合二甲双胍调脂效果明显,能降低C反应蛋白水平,不良反应少。
Objective To investigate the effects of atorvastatin combined with metformin on serum lipids and C-reactive protein in type 2 diabetic patients with hyperlipidemia. Methods 138 patients were randomly divided into two groups, the control group was given metformin, the observation group was given atorvastatin and metformin, observed before and after treatment of blood glucose, blood lipids and C-reactive protein levels. Results The hs-CRP and HDL-C in observation group were significantly lower than those in control group (P <0.05). Especially, the improvement of TC, TG, LDL-C and hs-CRP in observation group was better than that in control group. Conclusions Atorvastatin combined with metformin has obvious lipid-lowering effect, which can lower the level of C-reactive protein and less adverse reactions.