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简要地介绍了从血液中分离低密度脂蛋白 (L DL)技术的适应症 ,并对 L DL 吸附系统作了简单回顾 ,主要从合成短肽在去除血中 L DL 的应用出发 ,介绍了 4种新型吸附剂配体 (短肽 )的不同设计原理 :(1)利用静电吸引力的原理设计了带正电荷的短肽 ;(2 )根据 L DL 受体的配体结合位点肽段的特征设计短肽 ;(3)制备具有 L p(a)特征的短肽作为免疫原获取 L p(a)抗体 ;(4)用基因工程的方法人工合成低密度脂蛋白接合蛋白 (L BPs)片断用于与 L DL 的特异性结合。接着介绍了对吸附剂载体的设计要求。最后从合成短肽的角度出发 ,对血液净化法治疗家族性高脂血症作了展望
This article briefly introduces the indications for the separation of low-density lipoprotein (L-DL) from blood and briefly reviews the L-DL adsorption system. Starting from the application of synthetic short peptides in the removal of L-DL in blood, Different design principles of novel adsorbent ligands (short peptides): (1) The positively charged short peptides were designed based on the principle of electrostatic attraction; (2) According to the ligand binding site of L DL receptor (3) preparing a short peptide with Lp (a) characteristic as an immunogen to obtain Lp (a) antibody; (4) artificially synthesizing low density lipoprotein binding protein (LBPs) The fragment is used for specific binding to LDL. Then introduced the design requirements of the adsorbent carrier. Finally, from the perspective of the synthesis of short peptides, the prospective treatment of familial hyperlipidemia with blood purification