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2型糖尿病是导致动脉粥样硬化的重要高危因素之一，脂肪组织功能失调可能参与了糖尿病性动脉粥样硬化的发病过程。其中，脂肪组织内分泌功能异常和慢性低级别炎症反应在介导糖尿病相关动脉粥样硬化中发挥了重要作用。而新型脂质分子软脂酸羟基硬脂酸具有改善胰岛素敏感性及抗炎症作用，有可能成为干预糖尿病性动脉粥样硬化的新靶点。“,”Type 2 diabetes is one of the most important risk factors for atherosclerosis .The dysfunction of adipose tissue may be involved in the pathogenesis of diabetic atherosclerosis .And endocrine dysfunction and chronic low-grade inflammation in adipose tissue play important roles in mediating diabetes associated athero-sclerosis.A novel class of endogenous mammalian lipids palmitic-acid-hydroxy-stearic-acid with insulin sensi-tivity improving and anti-inflammatory effects is expected to become a new target for diabetes associated ath-erosclerosis intervention.