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目的:探讨术前中性粒/淋巴细胞比值(NLR)在阴茎癌患者预后评估中的价值。方法:回顾性分析1998~2013年在青岛大学附属医院泌尿外科行手术治疗的37例阴茎癌患者的资料。分析NLR与患者临床病理特征之间的关系,比较两组患者无进展生存率(PFS)和总生存率(OS)的差异。应用Kaplan-Meier法和Logrank检验进行生存分析,应用Cox比例风险回归模型进行独立危险因素分析。结果:高、低NLR组在年龄和淋巴结转移上的差异有统计学意义(P=0.04,P=0.008)。淋巴结转移(P<0.001,P<0.001)、远处转移(P=0.002,P=0.002)、病理分期(P<0.001,P<0.001)、NLR(P<0.001,P=0.022)分别与PFS和OS显著相关。多因素分析证实淋巴结转移、病理分期和NLR是影响PFS的独立危险因素(P=0.001,P=0.021,P=0.033)。结论:NLR是影响阴茎癌患者无复发生存率的独立危险因素,术前NLR≥2.3的患者预后差。
Objective: To investigate the value of preoperative neutrophil / lymphocyte ratio (NLR) in the prognosis evaluation of patients with penile cancer. Methods: The data of 37 patients with penile cancer undergoing surgical treatment in Department of Urology, Affiliated Hospital of Qingdao University from 1998 to 2013 were retrospectively analyzed. The relationship between NLR and the clinicopathological features of patients was analyzed. The differences of progression-free survival (PFS) and overall survival (OS) between the two groups were compared. Survival analysis was performed by Kaplan-Meier method and Logrank test, and independent risk factors were analyzed by Cox proportional hazards regression model. Results: There was a significant difference in age and lymph node metastasis between high and low NLR groups (P = 0.04, P = 0.008). (P <0.001, P <0.001), distant metastasis (P = 0.002, P = 0.002), pathological stage (P <0.001, Significantly related to OS. Multivariate analysis confirmed that lymph node metastasis, pathological stage and NLR were independent risk factors for PFS (P = 0.001, P = 0.021, P = 0.033). Conclusion: NLR is an independent risk factor for recurrence-free survival in patients with penile cancer. Patients with preoperative NLR≥2.3 have a poor prognosis.