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目的:研究不同胆囊疾病中E钙黏蛋白(E-cad)、血管内皮生长因子(VEGF)及增殖细胞核抗原(PCNA)的表达和分布的差异,探讨E-cad、VEGF和PCNA表达与胆囊癌临床病理特征的相关性及其预后判断的价值。方法:收集胆囊癌标本41例,胆囊腺瘤标本14例,慢性胆囊炎10例,应用免疫组化染色SP法分析。结果:胆囊癌VEGF阳性表达率(33/41)显著高于胆囊腺瘤(6/14)和胆囊炎(0/10),F=24·831,P=0·000,而E-cad阳性表达率(18/41)明显降低,伴有转移者E-cad表达(12/30)更低;胆囊癌PCNA LI高于胆囊腺瘤和胆囊炎组,H=19·03,P=0·008。VEGF过度表达者3年生存率(6/25)较阴性组(5/6)显著降低,F=8·286,P=0·008,PC-NA LI≥50者3年生存率(1/16)较<50者(10/15)显著降低,F=16·151,P=0·000;E-cad高表达者3年生存率(9/16)较阴性组(1/15)明显增高,F=12·511,P=0·001。结论:E-cad和VEGF及PCNA表达在胆囊癌、胆囊腺瘤与慢性胆囊炎之间差异均有统计学意义,均可作为评估胆囊良、恶性肿瘤的参考指标和胆囊癌预后判断的参考指标。
OBJECTIVE: To investigate the expression and distribution of E-cadherin, vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) in different gallbladder diseases and to explore the relationship between the expression of E-cad, VEGF and PCNA and gallbladder cancer Correlation of clinical and pathological features and prognostic value. Methods: 41 cases of gallbladder carcinoma specimens, 14 cases of gallbladder adenoma specimens and 10 cases of chronic cholecystitis were collected and analyzed by immunohistochemical SP method. Results: The positive expression rate of VEGF in gallbladder carcinoma (33/41) was significantly higher than that of gallbladder adenoma (6/14) and cholecystitis (0/10), F = 24.831, P = 0.000 while the positive expression of E-cad The expression of E-cadherin (12/30) was lower in patients with metastasis than in patients with gallbladder adenoma and cholecystitis (P <0.01) 008. The 3-year survival rate (6/25) of VEGF overexpression was significantly lower than that of the negative group (5/6). The 3-year survival rate of patients with VEGF-overexpression was (F = 8.286, P = 0.008, 16) was significantly lower than <50 (10/15), F = 16 · 151, P = 0.000; 3-year survival rate was significantly higher in E-cadherin group than in negative group (1/15) Increased, F = 12 · 511, P = 0.001. Conclusions: The expression of E-cad, VEGF and PCNA in gallbladder carcinoma, gallbladder adenoma and chronic cholecystitis have statistical significance, which can be used as a reference index to evaluate gallbladder benign and malignant tumors and prognosis of gallbladder carcinoma .