论文部分内容阅读
目的探讨小剂量阿司匹林联合硫酸镁治疗妊娠期高血压的临床疗效。方法选取2013年6月—2016年3月弋阳县中医院收治的妊娠期高血压患者80例,随机将患者分为对照组与观察组,各40例。对照组患者给予常规硫酸镁静脉滴注治疗,观察组在对照组治疗基础上给予小剂量阿司匹林口服治疗。比较两组患者治疗效果、治疗前后临床症状变化情况[收缩压、尿蛋白水平、动脉阻力指数(RI)]、并发症发生情况、生活质量评分。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者收缩压、尿蛋白水平、RI比较,差异无统计学意义(P>0.05);治疗后观察组收缩压、尿蛋白水平、RI低于对照组,差异有统计学意义(P<0.05)。观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。观察组患者活动能力、心理状态、社会能力、总评分高于对照组,差异有统计学意义(P<0.05)。结论小剂量阿司匹林联合硫酸镁治疗妊娠期高血压的临床疗效确切,可有效缓解患者临床症状,改善患者生活质量,且不良反应少。
Objective To investigate the clinical efficacy of low-dose aspirin plus magnesium sulfate in the treatment of gestational hypertension. Methods Eighty patients with gestational hypertension who were admitted to Yiyang Chinese Medicine Hospital from June 2013 to March 2016 were randomly divided into control group and observation group, 40 cases in each group. Control group patients given conventional intravenous magnesium sulfate treatment, the observation group in the control group based on the treatment given low-dose aspirin oral treatment. The changes of clinical symptoms, systolic pressure, urinary protein level, arterial resistance index (RI), complication and quality of life before and after treatment were compared between the two groups. Results The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). The systolic blood pressure, urinary protein level and RI in the two groups before treatment were not significantly different (P> 0.05). After treatment, systolic blood pressure, urinary protein and RI in the observation group were lower than those in the control group (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group, the difference was statistically significant (P <0.05). The activity, mental status and social ability of patients in observation group were higher than those in control group, with significant difference (P <0.05). Conclusion The low-dose aspirin combined with magnesium sulfate in the treatment of gestational hypertension clinical curative effect can effectively alleviate the clinical symptoms and improve the quality of life of patients with less adverse reactions.