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环孢素(Cycloporin A)是一种强力的免疫抑制剂,常用于实体器官移植、骨髓移植和自身免疫性疾病。肾毒性和高血压是环孢素治疗的严重副作用。环孢素引起肾毒性与前列腺素、肾素-血管紧张素轴和肾上腺素能神经系统相关。心房促尿钠排泄因子(ANF)是心房分泌的激素,可影响水电解质平衡和血压控制。动物实验证明,注入ANF 可阻止环孢素引起小鼠急性肾毒性,作者报道环孢素对葡萄膜炎患者 ANF 的影响。9例特发性葡萄膜炎患者接受环孢素(5
Cycloporin A is a potent immunosuppressive agent commonly used in solid organ transplantation, bone marrow transplantation and autoimmune diseases. Nephrotoxicity and high blood pressure are serious side effects of cyclosporine therapy. Cyclosporine-induced nephrotoxicity is associated with prostaglandins, renin-angiotensin axis and adrenergic nervous system. Atrial natriuretic factor (ANF) is a hormone secreted by the atrium and can affect water and electrolyte balance and blood pressure control. Animal experiments show that injection of ANF can prevent cyclosporine-induced acute nephrotoxicity in mice, the authors reported the impact of cyclosporine on patients with uveitis ANF. Nine patients with idiopathic uveitis received cyclosporine (5