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目的:观察自拟中药方联合针灸辅助治疗非小细胞肺癌的临床效果及对患者血清T细胞亚群的影响。方法:采用随机数字表法将丽水市中医院2015年11月至2018年11月收治的非小细胞肺癌患者104例分为观察组、对照组各52例。对照组采用动脉灌注化疗，观察组在化疗基础上采用自拟中药方联合针灸治疗。比较两组治疗前后的症状评分、血清T细胞亚群的变化，记录两组不良反应发生情况。结果:治疗后，对照组、观察组症状评分分别为(8.49±2.43)分、(8.41±2.21)分，均低于治疗前的(11.11±2.25)分、(6.23±2.02)分，差异均有统计学意义(n t＝104.962、82.738，均n P<0.001)，且观察组治疗后的症状评分低于对照组，差异有统计学意义(n t＝11.638，n P<0.001)。观察组治疗后肝功能损害发生率为15.38%(6/52)，明显低于对照组的34.62%(13/52)，差异有统计学意义(χn 2＝5.128，n P＝0.024)。治疗后观察组CDn 3＋、CDn 4＋、CDn 8＋、CDn 4＋/CDn 8＋分别为(63.24±20.40)%、(35.16±5.02)%、(27.55±13.54)%、(1.28±0.32)，较治疗前[(51.14±15.58)%、(25.64±6.19)%、(36.04±12.65)%、(0.71±0.11)]改善，差异均有统计学意义(n t＝18.103、58.675、68.789、19.573，均n P<0.001)，观察组改善情况均优于对照组的(55.84±15.21)%、(28.79±4.23)%、(32.51±9.51)%、(0.89±0.15)，差异均有统计学意义(n t＝2.097、6.997、2.162、7.958，均n P<0.05)。n 结论:自拟中药方联合针灸辅助治疗非小细胞肺癌患者可有效改善ⅢB、Ⅳ期非小细胞肺癌患者临床症状，提高免疫功能。“,”Objective:To observe the clinical effect of self-made traditional Chinese medicine combined with acupuncture and moxibustion in the treatment of non-small cell lung cancer, and its effect on the serum T cell subsets of patients.Methods:From November 2015 to November 2018, 104 patients with non-small cell lung cancer admitted to Lishui Hospital of Traditional Chinese Medicine were selected in the research.They were divided into observation group and control group according to random number table method, with 52 cases in each group.The control group was treated with arterial infusion chemotherapy, while the observation group was treated with traditional Chinese medicine decoction combined with traditional Chinese medicine acupuncture and moxibustion on the basis of chemotherapy.The clinical symptoms and serum T lymphocyte subsets of the two groups were observed and compared before and after treatment, and the adverse reactions of the two groups were recorded.Results:The symptom scores of the control group and the observation group were (8.49±2.43)points and (8.41±2.21)points, respectively, which were lower than those before treatment[(11.11±2.25)points and (6.23±2.02)points](n t=104.962, 82.738, all n P<0.05). The symptom score of the observation group was lower than that of the control group(n t=11.638, n P<0.05). The incidence of liver function damage in the observation group was 15.38%(6/52), which was significantly lower than that in the control group[34.62%(13/52)](χn 2=5.128, n P<0.05). After treatment, the immunologic indicators (CDn 3+, CDn 4+, CDn 8+, CDn 4+/CDn 8+) in the observation group were (63.24±20.40)%, (35.16±5.02)%, (27.55±13.54)%, (1.28±0.32), respectively, which were significantly improved compared with before treatment[(51.14±15.58)%, (25.64±6.19)%, (36.04±12.65)% and (0.71±0.11)], the differences were statistically significant (n t=18.103, 58.675, 68.789, 19.573, all n P<0.05). The improvements of immunological indicators in the observation group were better than those in the control group[(55.84±15.21)%, (28.79±4.23)%, (32.51±9.51)%, (0.89±0.15)], the differences were statistically significant (n t=2.097, 6.997, 2.162, 7.958, all n P<0.05).n Conclusion:Traditional Chinese medicine decoction combined with acupuncture and moxibustion can effectively improve the clinical symptoms, improve immune function and alleviate adverse reactions of chemotherapy in patients with stage Ⅲ B and Ⅳ non-small cell lung cancer.