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目的:探讨糖尿病胃轻瘫动物模型的制作,并对其进行评价。方法:目前糖尿病胃轻瘫模型的制作主要有单因素药物法和多因素药物与饮食结合的方法。结果:糖尿病胃轻瘫是糖尿病慢性并发症的多发病症,但一直未给予相应重视。对于糖尿病胃轻瘫的相关研究也较少报道。合适的动物模型可用来验证实验及临床假说,进而更有效地认识疾病的预防及发生、发展规律。结论:作者从糖尿病胃轻瘫的模型制作出发,对常用糖尿病胃轻瘫动物模型的制作方法,评价指标进行系统的回顾及评论,并提出目前模型制作所存在的问题,以期为糖尿病胃轻瘫研究提供帮助。
Objective: To investigate the animal model of diabetic gastroparesis and to evaluate it. Methods: At present, the model of diabetic gastroparesis is mainly made by single factor drug method and multi-factor drug combination with diet. Results: Diabetic gastroparesis is a frequent complication of chronic complications of diabetes, but has not been given the appropriate attention. Less research has been reported on diabetic gastroparesis. Appropriate animal models can be used to validate the experiments and clinical hypotheses, and then to more effectively understand the prevention, occurrence and development of diseases. CONCLUSIONS: From the model of diabetic gastroparesis, the author made a systematic review and comment on the making methods and evaluation indexes of the common animal models of diabetic gastroparesis, and put forward the problems in the current model making so as to provide a basis for diabetic gastroparesis Research helps.