论文部分内容阅读
美登木素是从 Maytenus serrata 及 buch-ananii 等东非灌木中分离得的 ansa 大环化合物,可延长 P388淋巴白血病、B16黑色素瘤及 Lewis 肺癌小鼠的生命。本文报导了美登木素在体外及体内对小鼠白血病的一些作用方式。结果表明,毫微克分子浓度的美登木素即可抑制培养细胞 L1210、L5178Y 及 P388的生长。其中以 P388最为敏感,处理48小时后的 ED_(50)为6×10~(-10)克分子,L1210与 L5178Y 的 ED_(50)分别
Maytansin is an ansa macrocyclic compound isolated from eastern African shrubs such as Maytenus serrata and buch-ananii, which can prolong the life of P388 lymphoid leukemia, B16 melanoma, and Lewis lung cancer mice. This article reports on the effects of maytansinol on murine leukemia in vitro and in vivo. The results showed that the nanomolar concentration of maytansin inhibited the growth of cultured cells L1210, L5178Y and P388. Among them, P388 is the most sensitive, and the ED_(50) after 48 hours of treatment is 6×10 -10 mol, and the ED_(50) of L1210 and L5178Y are respectively