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目的探究曲美他嗪对左心室射血分数保留性心衰(HFp EF)患者心功能及B型钠尿肽(BNP)的影响。方法选取80名HFp EF患者视为研究对象,所有患者按照随机平均法分成治疗组(n=40)和对照组(n=40)。对照组患者给予实施常规基础治疗;观察组在常规治疗的基础上加用曲美他嗪口服治疗。3个月后比较两组等容舒张时间(IRT)、舒张早期血流峰值速度(E)、舒张晚期血流峰值速度(A)、舒张早期血流峰值速度/舒张晚期血流峰值速度(E/A)、血浆标志物BNP、六分钟步行试验。结果与治疗前比较,两组治疗后IRT、E、A、E/A、BNP均改善,六分钟步行距离均增加,差异有统计学意义(P<0.05);治疗组疗效优于对照组,差异有统计学意义(P<0.05);两组患者的不良反应率无明显差异(P>0.05)。结论常规治疗基础上联合曲美他嗪治疗左心室射血分数保留性心力衰竭,能够改善患者心中舒张功能,降低BNP水平,提高患者的生存质量。
Objective To investigate the effect of trimetazidine on cardiac function and B-type natriuretic peptide (BNP) in patients with preserved left ventricular ejection fraction (HFp EF). Methods Eighty patients with HFp EF were enrolled as study subjects. All patients were divided into treatment group (n = 40) and control group (n = 40) according to randomized average method. Patients in the control group were given routine basic treatment; the observation group was treated with trimetazidine orally on the basis of routine treatment. Three months later, the isometric relaxation time (IRT), early peak diastolic velocity (E), late diastolic peak velocity (A), early diastolic peak velocity / late diastolic peak velocity (E / A), plasma marker BNP, six-minute walk test. Results Compared with those before treatment, the levels of IRT, E, A, E / A and BNP in both groups improved and the distance of walking in six minutes increased after treatment. The difference was statistically significant (P <0.05) The difference was statistically significant (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Conventional treatment combined with trimetazidine in the treatment of left ventricular ejection fraction preserving heart failure can improve diastolic function, reduce BNP level and improve patients’ quality of life.