利福平(甲呱力复霉素Rifampin)是一半合成广谱抗生素,有强力的杀菌作用,尤其对结核杆菌有效。但近年来常有关于利福平致肝功能受损、转氨酶升高等副反应的临床报道。为此,我们研制利福平粉末气雾剂,以提高病灶部位的药物浓度,减少用药总量,以期降低副反应。 Rifampin is a half-synthesized broad-spectrum antibiotic that has a powerful bactericidal effect, especially against Mycobacterium tuberculosis. But in recent years, there are often reports of rifampin-induced liver damage, elevated aminotransferases and other side effects of clinical reports. To this end, we developed rifampicin powder aerosol, to enhance the concentration of drug concentration in the lesion, reducing the total amount of medication, with a view to reduce side effects.