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青蒿素为一新类型抗疟药,是我国学者从黄花蒿Artemisia annua L.中分得的含过氧基团的倍半萜内酯,它的化学结构和性质已有报道.从生源角度看,青蒿素属桉叶醇内酯(Eudesmeaolide)型,目前国内外对此类醇内酯的~(13)C NMR研究较少.本文报道青蒿素(1)及其一些类似物(2~9)的~(13)C NMR的谱线归属及其取代基效应的研究,以便为这类化合物的结构鉴定提供某种判据.
Artemisinin, a new type of anti-malarial drug, is a sesquiterpene lactone containing peroxy group, which is obtained from Chinese Artemisia annua L. The chemical structure and properties of artemisinin have been reported. As a result, artemisinin is a type of Eudesmeaolide, and ~ (13) C NMR studies on this kind of alcohol lactones are few at home and abroad.In this paper, artemisinin (1) and its analogues 2 ~ 9) ~ (13) C NMR spectral line assignments and their substituent effects in order to provide some evidence for the structural identification of these compounds.