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目的 研究增生性玻璃体视网膜病变 (proliferative vitreoretinopathy,PVR)的视网膜前膜 (epiretinal m embranes,ERM)中炎性细胞因子白细胞介素 - 1β(interleukin- 1β,IL- 1β)、白细胞介素 - 6 (interleukin- 6 ,IL- 6 )、白细胞介素 - 8(interleukin- 8,IL- 8)和肿瘤坏死因子 - α(tum or necrosis factor- α,TNF- α)的表达及其作用。方法 用免疫组织化学方法对19例复杂性视网膜脱离行玻璃体切割术时剥离的视网膜前膜进行观察。结果 IL- 1β、IL-6、IL- 8和 TNF- α分别在 9、12、11和 15例视网膜前膜中表达 ,尤其以细胞外基质中明显 ,4种细胞因子在 4例膜中同时表达 ,仅有 1例膜中细胞内表达 IL- 6。结论 增生性玻璃体视网膜病变的发病机理中有细胞因子介导的炎症途径参与
Objective To study the expression of inflammatory cytokines interleukin-1β (IL-1β), interleukin-6 (IL-1β) and interleukin-6 interleukin-6 and IL-6, interleukin-8 and tumor necrosis factor-α (TNF-α) Methods The retinal detachments of 19 patients with complex retinal detachment during vitrectomy were observed by immunohistochemistry. Results IL-1β, IL-6, IL-8 and TNF-α were expressed in 9, 12, 11 and 15 cases of pre-retinal membrane respectively, especially in the extracellular matrix. Four kinds of cytokines Expression, and only 1 of the cells expressed IL-6 in the cells. Conclusions There are cytokine-mediated pathways involved in the pathogenesis of proliferative vitreoretinopathy